Ho tloha ka selemo sa 2007, re ba bang ba ba etelletseng pelephofo ea orlistatmofani oa thepa ka China
Orlistat (CAS NO.96829-58-2) ke lithethefatsi tse etselitsoeng ho phekola botenya.E sebelisoa haholo-holo ho thibela ho kenngoa ha mafura lijong tsa batho, kahoo ho fokotsa ho kenngoa ha caloric.Ntle ho moo, e reretsoe ho sebelisoa hammoho le ngaka e hlokometsoeng e fokotsehileng-khalori lijo.
| Ntho | Litlhoko | Liphetho tsa liteko |
| Ponahalo | ha e ntse e le phofo | Phofo e tšoeu |
| Boitsebiso | HPLC nako ea ho boloka | E lumellana |
| Melting Point | 42 ºC -45°C | 42°C-44°C |
| Potoloho e khethehileng ea optical | -31.0°~-41.0° | -36.0° |
| Bohloeki ka HPLC | eseng ka tlase ho 98.0% | 98.5% |
| Ho se hloeke ho feletseng | eseng ho feta 2.0% | 1.6% |
| Ho se hloeke ho hoholo hoa motho ka mong | eseng ho feta 0.5% | 0.3% |
| Likahare tsa metsi%(K&F) | eseng ho feta 0.5% | 0.1% |
| Li-solvents tse setseng | EtOH eseng ho feta 0.5% | ND |
| EtAC ha e fete 0.5% | ND | |
| n-Heptane ha e fete 0.5% | ka tlase ho 0.1% | |
| Mesaletsa ha e tuka | ka tlase ho 0.2% | 0.10% |
| Limetale tse boima joalo ka Pb | eseng ho feta 20ppm | ka tlase ho 20ppm |
| Assay (HPLC) | eseng ka tlase ho 98.0% | 99.60% |
| Qetello | E Kopana le Litlhoko | |
Orlistat ke sethethefatsi se secha se tsebahalang lefatšeng ka bophara sa ho theola boima ba 'mele.Lebitso la eona la khoebo ke Sainike 'me le qalile ho rekisoa New Zealand ka 1998. Orlistat ke nako e telele le e sebetsang hantle haholo ea gastrointestinal lipase inhibitor, 'me ha e qhibilihe metsing, e qhibiliha ka chloroform,' me e qhibiliha habonolo ka ethanol.
Orlistat e ka sebelisoa tleliniking ho phekola botenya.Hangata, tekanyo ea 120mg e nkoa ka makhetlo a mararo ka letsatsi nakong ea hora e le 'ngoe ea lijo.Ho lahleheloa ke boima ba 'mele ho qala ho etsahala ka mor'a libeke tse peli tsa tšebeliso.E ka sebelisoa ka ho tsoelang pele bakeng sa likhoeli tse 6-12, 'me liphello tsa eona li tla khaotsa ho eketseha ka mor'a hore tekanyo ea letsatsi le letsatsi e fete 400mg.Setlhare sena se loketse ho sebelisoa hammoho le lijo tse nang le lik'halori tse tlaase ke batho ba batenya le ba batenya, hape li ka sebelisoa e le phekolo ea nako e telele bakeng sa bakuli ba tobaneng le maemo a kotsi a amanang le boima ba 'mele.Orlistat e na le phello ea nako e telele ea ho laola boima ba 'mele e fokotsang le ho boloka boima ba' mele le ho thibela ho khutlela morao.Ho sebelisa Orlistat ho ka fokotsa liketsahalo tsa likotsi le mafu a amanang le boima ba 'mele, ho kenyelletsa hypercholesterolemia, lefu la tsoekere la mofuta oa 2, ho se mamelle tsoekere, hyperinsulinemia le khatello ea mali,' me e ka fokotsa mafura a litho tsa 'mele.Orlistat e boetse e fetola maemo a lipid a mali: e ka fokotsa serum triglycerides (TG) le low density lipoprotein cholesterol (LDL-C), mme e ka eketsa karo-karolelano ea lipoprotein tse phahameng ho isa ho lipoprotein tse tlase ho bakuli ba batenya.
Hebei Guanlang Biotechnology Co., Ltd. ke ea Sehlopha sa Guanlang, se thehiloeng ka 2007, se toropong ea Shijiazhuang e leng motse-moholo oa Profinse ea Hebei le setsi sa setsi sa Beijing Tianjin le Hebei 'me se na le monyetla oa lipalangoang tse bonolo.Khamphani ea rona ke khoebo ea sejoale-joale ea theknoloji e phahameng ea lik'hemik'hale e nang le Lipatlisiso le Nts'etsopele, tlhahiso le thekiso.
